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National Institutes of Health · PA-27-102
NIH Parent STTR
Biomedical product development through a small-business partnership with a nonprofit research institution.
Next deadline:
Read the full official announcement ↗Key information
- Mechanisms
- R41/R42: Phase I, Phase II, Direct to Phase II and Fast-Track.
- Eligibility
- Eligible U.S. small businesses with qualifying ownership and up to 500 employees including affiliates. The award goes to the company.
- Research partnership
- At least 40% of research effort by the company and 30% by one partner research institution. The PI may work for either organization.
- Funding & duration
- Institute-specific budgets and waiver topics appear in Section II. Normally up to 1 year for Phase I and 2 years for Phase II.
- Clinical trials
- Optional, subject to participating institute restrictions.
- Future deadlines
- January 5 and April 5, 2027, at 5 p.m. applicant organization’s local time. Expires April 6, 2027. Late applications are not accepted.
- Application & review
- Follow NIH SBIR/STTR instructions and Section IV; use ASSIST, Grants.gov Workspace or an institutional system. See Section V for review criteria.
- Contact
- NIH SEED: SEEDinfo@nih.gov; consult institute-specific contacts for scientific fit.
Summary checked September 12, 2026. The official announcement, amendments and application guide govern eligibility and submission requirements.
Application & review timeline
- Begin preparationSuggested start date
- Application due5 p.m. local time
- Scientific reviewNIH peer review
- Council reviewAdvisory council
- Earliest project startIf funded
Preparation start is a Noradelis suggestion. Review and earliest start dates follow the announcement and may change; an award is not guaranteed. Timeline not to scale.
Official sources
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